Preheat oven to 400 degrees. Melt 1/4 cup butter in a large sauce pan over medium-high heat. Add flour; cook, whisking constantly, for 1 minute. Whisk in milk and 3 cups water. Bring to a boil, reduce heat to a simmer, and cook, whisking often, until a very thin, glossy sauce forms, about 10 minutes (don't rush this). Stir in 1 T salt and the pepper. Remove from heat. Toss pasta and 2 cups of cheese in a 9x13x2 baking dish. NOTE: this is where you would add any additional ingredients. Pour sauce over and cover with foil. Bake until pasta is almost tender, about 25-30 minutes. If using the topping. While the pasta bakes, melt the remaining butter in a large skillet over medium heat, Add the garlic, panko, and parsley and toss to combine. Season with salt and pepper. Remove foil from dish. Sprinkle with remaining cup of cheese. If using, top with the the panko mixture. Bake until pasta is tender, edges are bubbling, and top is golden brown, about 20 minutes longer. Note: if not brown enough give it a few minutes under the broiler. Let stand for 10 minutes before serving.