In a large bowl, combine buttermilk, salt, sugar, pepper, garlic powder, and hot sauce.Combine chicken and buttermilk marinade in a large bowl, refrigerate 12 to 24 hours.When ready to fry, drain chicken and coat with all purpose flour. Fry in vegetable oil heated between 300 and 325 degrees F until done throughout (approximately 12 to 15 minutes on each side).