Cook bacon in a large nonstick pan. Remove, crumble, and set aside. Add butter to grease in pan and cook onion until soft. Add flour to pan and cook, stirring, for 1 minute. Gradually whisk in milk. Bring to a simmer and remove from heat. Stir in 1 teaspoon cajun seasoning. Set aside 1/2 cup cheddar cheese and stir remaining cheddar cheese and Parmesan cheese in until melted. Check for seasoning and add salt to taste. Drain crab and stir into cheese mixture. Place cooked pasta in a 9X13-inch casserole dish. Pour cheese sauce on top and mix. Sprinkle reserved cheese on top along with bacon. In a small bowl, stir together Panko crumbs and melted butter. Sprinkle on top of mac and cheese. Bake in a 350 degree oven for 15 minutes. Broil for 2-3 minutes (watching closely) to brown bread crumbs.